Development of [C]erlotinib Positron Emission Tomography for In Vivo Evaluation of EGF Receptor Mutational Status
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چکیده
Purpose: To evaluate whether, in patients with non–small cell lung carcinoma (NSCLC), tumor uptake of [C]erlotinib can be quantified and imaged using positron emission tomography and to assess whether the level of tracer uptake corresponds with the presence of activating tumor EGF receptor
منابع مشابه
Imaging, Diagnosis, Prognosis Development of [C]erlotinib Positron Emission Tomography for In Vivo Evaluation of EGF Receptor Mutational Status
Purpose: To evaluate whether, in patients with non–small cell lung carcinoma (NSCLC), tumor uptake of [C]erlotinib can be quantified and imaged using positron emission tomography and to assess whether the level of tracer uptake corresponds with the presence of activating tumor EGF receptor
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PURPOSE To evaluate whether, in patients with non-small cell lung carcinoma (NSCLC), tumor uptake of [(11)C]erlotinib can be quantified and imaged using positron emission tomography and to assess whether the level of tracer uptake corresponds with the presence of activating tumor EGF receptor (EGFR) mutations. EXPERIMENTAL DESIGN Ten patients with NSCLCs, five with an EGFR exon 19 deletion, a...
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BACKGROUND Non-small cell lung carcinoma (NSCLC) represents approximately 80% of lung cancer cases, and over 60% of these tumors express the epidermal growth factor receptor (EGFR). Activating mutations in the tyrosine kinase (TK) domain of the EGFR are detected in 10% to 30% of NSCLC patients, and evidence of their presence is a prerequisite for initiation of first-line therapy with selective ...
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تاریخ انتشار 2012